Chronic pain conditions can cripple you for life. Daily chores become a struggle when you are down with painful health conditions. Fortunately, we have access to some of the fast-acting pain management medicines. Some of them are available over-the-counter while some can be purchased with a valid prescription.

Tapentadol 100mg UK is one of the best pain management medicines available on the market. Alongside, there are other painkillers accessible. Nevertheless, it becomes a little difficult to choose from the available range of medicines for long-term pain management.

In this article, we will be analyzing pain medicines for their effectiveness, side effects profile, and other aspects to decide which one is better and reliable. Please note that this article is purely for informational and educational purposes. We do not advice our readers to self-diagnose their symptoms and choose medicines by themselves especially after reading this piece of information.

Brief information on Tapentadol

It is an opioid medicine available with a prescription. It is useful in the treatment of moderate to severe pain caused by musculoskeletal and neurological conditions. This medicine is prescribed when non-opioid medicines fail to manage the pain, or when you develop allergic reactions to these meds.

This pain management medicine is prescribed for a short treatment plan. The medicine works on the opioid receptors in the CNS and cut off the transmission of pain signals from the body to the brain.

Mechanism action of Tapentadol

Image courtesy: https://www.researchgate.net/figure/Schematic-drawing-of-the-dual-mode-action-of-tapentadol-Reproduced-with-permission-from_fig1_333120787

Tapentadol is a fast-acting synthetic pain relieving medicines which has a dual action of mechanism. This medicine is a mu-opioid receptor agonist and it also blocks the reuptake of norepinephrine.

The mechanism of action is unclear yet. The medicine is a selective mu-opioid receptor (MOR) agonist which binds to MOR. It has greater than or equal to ten-fold greater affinity to bind to MOR than delta- and kappa- receptors. This opioid pain reliever medicine also inhibits the reuptake of noradrenaline which results in the increased levels of the neurotransmitter. Furthermore, this process activates alpha-2 receptors to induce analgesia which means the suppression of pain.

Shall I buy Tapentadol 100mg online or other pain killers?

A round-the-clock pain management is possible with this opioid medicine. It is a fast-acting opioid pain reliever that delivers faster results than most of the pain killer drugs. Nevertheless, there are other pain management medicines available that are used popularly.

A chart comparing all aspects of majorly used popular pain management medicines is given below:

	Tapentadol	Tramadol	Gabapentin
Indications	This medicine is used to reduce moderate to severe pain caused by musculoskeletal conditions and diabetic neuropathy.	It’s a strong opioid medicine used in the management of moderate to severe pain and nerve pain.	It’s an anti-convulsant medicine with pain relieving properties used to treat seizures, and nerve pain.

Dosage forms	Oral tablets	· Oral capsules (Extended release) · Oral tablet (Regular) · Oral tablet (Extended release) · Oral liquid	· Oral capsule · Oral tablet (Regular) · Oral tablet (Extended release) · Oral solution

Side effects	· Constipation · Heartburn · Stomach upset · Weakness	· Drowsiness · Constipation · Dry mouth · Joint pain · Heartburn	· Poor concentration · Mood swings · Clumsiness · Restlessness

Brand names	Nucynta, Nucynta ER, Aspadol	ConZip, Qdolo, Tramadol Hydrochloride ER	Fanatrex, Gabarone, Gralise, Neurontin

Half-life	4 Hours	5.2 Hours	6 Hours

Potential for abuse	This medicine has a high potential for abuse. Therefore, it has to be consumed under stringent medical supervision, and for a prescribed period of time.	Tramadol has a low abuse potential causing symptoms such as physical or psychological dependency.	It is not a controlled drug.

Alcohol interaction	Alcohol increases the severity of side effects caused by Tapentadol 100mg pills. You may experience severe dizziness, sleepiness, poor concentration, etc.	When consumed with alcohol, Tramadol causes severe side effects including dizziness, drowsiness, etc.	Gabapentin interacts with alcohol causing severe dizziness and sleepiness.

Pregnancy warnings	This medicine should be taken only when its benefits outweigh the risk to the growing fetus.	Due to insufficient clinical data available, this medicine should NOT be consumed during pregnancy.	It can only be consumed when the benefits outweigh the risk to the fetus.

Take away message

Before you buy Tapentadol 100mg online UK, or other pain killer medicines, you can go through this comparison chart to make a better decision. It is imperative to consult a healthcare provider before taking any of these medicines.

Ref. links

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318929/

https://www.drugs.com/compare/tapentadol

https://www.healthdirect.gov.au/tapentadol#:~:text=a%20specific%20medication.-,What%20is%20tapentadol%20used%20for%3F,(long%20term)%20pain%20conditions.

https://go.drugbank.com/drugs/DB06204